Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Polygalasaponin F 是从瓜子金中提取的齐墩果烷型三萜皂苷,可通过调节TLR4-PI3K/AKT-NF-kB 信号通路减少神经炎症细胞因子的分泌,能降低炎性细胞因子肿瘤坏死因子 α 的释放。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
20 mg | ¥ 610 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 710 | 现货 |
产品描述 | Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Polygalasaponin F can significantly inhibit the cytotoxicity of conditioned medium prepared by LPS-stimulated BV-2 microglia (LPS conditioned media) to neuronal PC12 cells and improve cell viability. Polygalasaponin F can induce long-term potentiation in hippocampal dentate gyrus in anesthetized rats via NMDAR activation mediated by Ca(2+)/calmodulin-dependent kinase II, extracellular signal-regulated kinase and cAMP response element-binding protein signaling pathway. PS-F inhibits the secretions of neuroinflammatory cytokines by the regulation of the NF-kB-signaling pathway. |
别名 | 异牡荆苷, 瓜子金皂苷己 |
分子量 | 1091.24 |
分子式 | C53H86O23 |
CAS No. | 882664-74-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (54.98 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 0.9164 mL | 4.5819 mL | 9.1639 mL | 22.9097 mL |
5 mM | 0.1833 mL | 0.9164 mL | 1.8328 mL | 4.5819 mL | |
10 mM | 0.0916 mL | 0.4582 mL | 0.9164 mL | 2.291 mL | |
20 mM | 0.0458 mL | 0.2291 mL | 0.4582 mL | 1.1455 mL | |
50 mM | 0.0183 mL | 0.0916 mL | 0.1833 mL | 0.4582 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Polygalasaponin F 882664-74-6 Cytoskeletal Signaling Immunology/Inflammation NF-Κb PI3K/Akt/mTOR signaling NF-κB PI3K TLR Akt Phosphoinositide 3-kinase Nuclear factor-kappaB inhibit Protein kinase B PKB 异牡荆苷 Nuclear factor-κB Toll-like Receptor (TLR) Inhibitor 瓜子金皂苷己 inhibitor